Actinomycin D as an Epimutagen in Protists

Zoya I. Uspenskaya,

Alexander L. Yudin


A previously unrecorded property of actinomycin D, a well-known antibiotic, was discovered in the course of long-term genetic research on the amoeba Amoeba proteus and the ciliate Dileptus anser. In these protists actinomycin D can induce an unusual type of hereditary variation, which we refer to as the inheritable destabilization of characters. A number of features indicate that this variation is epigenetic, that is, not caused by mutations in the DNA. Therefore, actinomycin D may be considered as an inducer of epigenetic inheritable changes, in other words, as an epimutagen.


Słowa kluczowe: actinomycin D, Amoeba proteus, Dileptus anser, epigenetic variation, epimutagen, inheritable destabilization of characters

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