Rheological properties of primary pharmaceutical emulsions obtained by homogenization

Barbara Tal-Figiel

Abstrakt

The paper presents the results of rheological examinations of primary emulsions with the potential for pharmaceutical applications, created through emulsification using a homogeniser. The water phase of the examined emulsions was made up of water solutions of hydrocolloids, the fatty phase was the pharmaceutical oil Miglyol 812N and canola oil, sunflower seed oil, olive oil. For the determination of relations between the structural parameters of the emulsions and their viscous properties flow curves and viscosity curves were obtained for the examined systems. The obtained results were processed through regression of experimental points by rheological equations, using the own software of the rheometer.

Słowa kluczowe: emulsion, rheology, flow and viscosity curve
References

S i n g h S.K., M i s h r a D.N., J a s s a l R., S o n i P., Fast disintegrating combination tablets of omeprazole and domperidone, Asian J. Pharm. Clinic Reserch, 2009, 2, (3), 74.

A b d e l b a r y G., P r i n d e r r e P., E o u a n i C., J o a c h i m J., R e y n i e r J.P., P i c c e r e l l e Ph., The preparation of orally disintegrating tablets using a hydrophilic waxy binder, Inter. J. Pharm. 2004, 278, 423.

D o b e t t i L., Fast-Melting Tablets: Developments and Technologies, Pharm. Techn. Europe 2000,12,(9), 32.

A h m e d I., A b o u l - E i n i e n M., In vitro evaluation of fast disintegrating lyophilized dry emulsion tablet containing griseofulvin, Eur. J. Pharm. Sci., 2007, 32, 58.

Ta k e u c h i H., S a s a k i H., N i w a T., H i n o T., K a w a s h i m a Y., U e s u g i K., O z a w a H., Redispersible dry emulsion systems as novel oral dosage form of oily drugs: In vivo studies in Beagle dogs, Chem. Pharm. Bull., 1991, 39, (12), 3362.

C o r v e l e y n S., R e m o n J.P., Formulation and production of rapidly disintegrating tablets by lyophilisation using hydrochlorothiazide as a model drug, Inter. J. Pharm. 1997, 152, 215.

C o r v e l e y n S., R e m o n J.P., Formulation of a lyophilized dry emulsion tablet for the delivery of poorly soluble drugs, I. J. Pharm., 1998, 166, 65.

C h r i s t e n s e n K.L., P e d e r s e n G.P., K r i s t e n s e n H.G., Physical stability of redispersible dry emulsion containing amorphous sucrose, Eur. J. Pharm. Biopharm., 2002, 53, 147.

Vy a s S.P., J a i n C.P., K a u s h n i k A., D i x i t V.K., Preparation and characterization of griseofulvin dry emulsion, Pharmazie 1992, 47, (6), 463.

D o l l o G., L e C o r r e P., G u e r i n A., C h e b a n n e F., B u r g o t J.L., L e v e r g e R., Spray-dried redispersible oil-in-water emulsion to improve oral bioavailability of poorly soluble drugs, Eur. J. Pharm. Sci., 2003, 19, 273.

C h r i s t e n s e n K.L., P e d e r s e n G.P., K r i s t e n s e n H.G., Technical optimisation of redispersible dry emulsions, Inter. J. Pharm. Biopharm., 2001, 212, 195.

C h r i s t e n s e n K.L., P e d e r s e n G.P., K r i s t e n s e n H.G., Preparation of redispersible dry emulsion by spray drying, Inter. J. Pharm. Biopharm., 2001, 212, 187.

L l a d s e r M., M e d r a n o C., The use of supports in the lyophilization of oil-in-water emulsions, J. Pharm. Pharmacol., 1986, 20, 450.

R i c h t e r V.A., S t e i g e r - T r i p p i K., Untersuchungen über die zerstäbungstrocknung von emulgierten arzneizubereitungen, Pharm. Acta Helv., 1961, 36, 322.

C o r v e l e y n S., R e m o n J.P., Bioavailability of hydrochlorothiazide: conventional versus freeze-dried tablets, Int. J. Pharm., 1998, 173, 145.

Farmakopea Polska VII.

K i e k e n s F., Ve r m e i r e A., S a m y n N., Optimisation of electrical conductance measurements for the quantification and prediction of phase separation in o/w-emulsions, containing hydroxypropylmethylcelluloses as emulsifying agents, Int. J. Pharm., 1997, 146, 239.